The disease is autosomal recessive. The genetic defect is in the HbS gene (Meremikwu, 2009). HbS mutation arises from a mutation that substitutes thymine for adenine in the 6th codon of the gene of beta chain, GAG to GTG. This change leads to coding of valine instead of glutamate in the 6th position of Hb chain. This type of hemoglobin is known as HbS which polymerizes easily under certain circumstances and alters the morphology of RBCs. Homozygous disease is the most severe form (Meremikwu, 2009). Sickle cell disease is most common in individuals residing in or originating from sub-Saharan Africa. It also affects individuals from Caribbean, Meditteranean, Asian and Middle-eastern origin. "About 60,000 people in the US[ and 10,000 in the UK suffer from the disease" (Meremikwu and Okomo, 2011). "Sickle cell disease (SCD), the most common inherited blood disorder in the United States, is caused by a mutation in the hemoglobin-beta gene found on chromosome 11" (Parsh, 2013).According to Aljiburi et al (2012), "Sickle cell disease (SCD) is the most common inherited blood disorder in England."Pathophysiology and Pathogenesis The abnormality in sickle cell disease lies in the hemoglobin. The molecule is mutated and is known as HbS. When deoxygenated, the HbS molecules polymerize to form psuedocrystalline structures called tactoids. These distort the red cell membranes making them form a characteristic sickle cell appearance. Sickling of cells mainly occurs in regions of microvasculature where blood flow is sluggish. Sickled cells incre
In the paper “Sickle Cell Anemia in Adults” the author examines sickle cell anemia which is a pathological condition that manifests in early infancy. The condition is associated with morbidity and mortality and many children succumb to its complications in childhood and adolescence…
Most pregnant women fear telling their husbands that they should go, be screened, and would rather give birth to children who have sickle cell anaemia. The contributory factor to sickle cell anaemia is the fact that most people lack education about the disease and so are not aware about it.
This study will be guided by the following research questions: What is the level of knowledge among pregnant women with the sickle cell trait from the Mississippi Delta about sickle cell disease? What are the attitudes of pregnant women with the sickle cell trait from the Mississippi Delta about sickle cell disease?
This paper take a look at some of the various ways that the disease affects the lives of people and how this disease can be controlled and managed without causing death. A series of articles and books have been used here as the main sources for getting the useful information used here.
One in 12 African – Americans and 1 in 100 Hispanic –Americans has sickle cell trait (CDC 2007). It also occurs in people who originate from the Middle East, India, and Eastern Mediterranean areas. The complications associated with this trait are mild and minimal and also people with this trait are as healthy as individuals who do not have this trait, but it assumes significance because children can inherit the sickle cell gene.
It is the oxygen carrier in blood. In other words, Hemoglobin is responsible for distributing oxygen to different body organs. It should be noted that adequate oxygen supply is necessary for many of the body organs to function well. So any defects occur to the Hemoglobin can cause problems in the functioning of different body organs.
The article describes the condition of Ryan Clark, safety of Pittsburgh Steelers and the reason why he has been restricted from playing in the upcoming game against the Denver Broncos. The writer has described the limitations a professional player has to face because of sickle cell trait and has also highlighted the underlying pathology of the blood disorder.
The diseased individuals inherit the genes from their affected parents and pass it on to their offspring. In sickle cell disease, abnormal haemoglobin S replaces the normal haemoglobin A due to alterations in the genes. The function of haemoglobin is to transport oxygen and deliver it to the different organs and cells of the human body.
Around 70,000 people, who are from sub African, even though there are some reports in India, some parts of central and South American areas, southern parts of Europe, and Caribbean regions mostly experience sickle cell anemia. Several children do not show any
ife she has lived, her days of no pain are very countable, and my one greatest fear is that she may never make it to the age of 40 because of the long term effects and prognosis of the disease.
Sickle cell anemia is a non treatable hereditary problem which has an effect on the
1 pages (250 words)Research Paper
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