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COLORECTAL CANCER Name of Tutor Subject April 14, 2013 Student’s name Role of Fluorouracil and John’s side effect Fluorouracil is an anti-cancer (antineoplastic or cytotoxic) chemotherapy drug. It is classified as an antimetabolite and is administered for treatment of Colon and rectal cancer, breast cancer, gastrointestinal cancers among other forms of cancer (Center, 2009).
The main side effect exhibited in John in the case study is general fatigue, which may be attributed to the fluorouracil administered to him. The relationship between such side effect and fluorouracil can be accounted for by how it works in that its most effective at killing cells that are rapidly dividing (cancerous cells) (Knowles, 2007). Unfortunately it does not know the difference between the cancerous cells and the normal cells and thus normal cells are adversely affected. Although the normal cells will grow back and be healthy in the meantime side effect in which case fatigue occur. The "normal" cells most commonly affected by fluorouracil are the blood cells which account for a drop in hemoglobin levels as can be said of John which dropped to 100 from the normal level of 130-180/liter of blood. Interventions to Manage side effect experienced by John Cancer-related fatigue, defined by the National Comprehensive Cancer Network (NCCN) as a persistent, subjective sense of tiredness related to cancer or cancer treatment that interferes with usual functioning of an individual can be described in terms of perceived energy, mental capacity, and psychological status (Choo, 2008). It arises over a continuum, ranging from tiredness to exhaustion. ...
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