Pharmacotherapeutics of Metoclopramide and Co-danthramer drugs Name: University: Course: Date: Introduction The major aim of this paper was to explore various aspects related to the Pharmacotherapeutics of Metoclopramide 10mg and co-danthramer drugs on the patient with nausea and constipation as well as with gastric cancer…
Vomiting is the forcible involuntary or voluntary stomach contents emptying ("throwing up") through the mouth (Schnell F, 2003) .However vomiting, nausea and constipation might be as a result of gastric cancer related complications that the patient had. To really understand how this condition of the patient can be managed or treated, the Pharmacotherapeutics of these two suggested drugs has been discussed in detail. Metoclopramide 10mg is used in the treatment of vomiting, Digestive disorders, Nausea and Migraine. Metoclopramide increases the muscles contractions or movements in the intestines and stomach (Schnell F. 2003). These results to a decrease in the duration the stomach contents take to move through the digestive tract. On the other hand, Co-danthramer suspension and capsules have 2 active ingredients, Poloxamer 188 and Dantron. Both of these drugs are referred to as laxatives. Hence in combination it is called co-danthramer. Dantron is laxative type referred to as stimulant laxative. It acts by nerve endings stimulation in the intestines walls. This results to intestinal wall muscles to contract frequently with increased force. The gut’s contents are moved along the intestines as a result of these muscles contraction, hence relieving constipation. Poloxamer 188 is referred to as faecal softener. It aids in drawing water into the faecal material, hence the water content and stools volume is increased. This makes it easier and softer to pass. Therefore these drugs best suit the treatment of this patient condition and its Pharmacotherapeutics have been explored in the next section. Pharmacotherapeutics of Metoclopramide and Co-danthramer Pharmacokinetics of Metoclopramide Metoclopramide is well and rapidly absorbed. Relative to 10 mg intravenous dose, the absolute oral Metoclopramide bioavailability is 80% ± 15.5% (Baxter Healthcare Corporation, 2010) .This was indicated in a crossover study which had 18 subjects. Concentrations of Peak plasma are experienced at approximately 1 - 2 hours following a single oral dose. It is also observed that same time to peak can be experienced at steady state following individual doses (Baxter Healthcare Corporation, 2010). According to a single dose study carried out on 12 subjects, it was observed that the area under the drug concentration-time curve linearly increased with doses to 100 mg from 20(Jordan et al, 2004). This means that the Concentrations of Peak linearly increase with dose, but time concentrations of peak don’t change; whole body clearance doesn’t change; and the rate of elimination doesn’t change (remains the same) (Jordan et al, 2004). In normal renal function individuals, the half-life of average elimination is 5 - 6 hours. Processes of Linear kinetic describe the Metoclopramide elimination and absorption (Baxter Healthcare Corporation, 2010). In a certain study carried out, it was observed that about 85% of the radioactivity of Metoclopramide dose which was administered orally appeared in the urine within 72 hours. Out of this eliminated 85% in the urine, approximately half of it was present as conjugated or free Metoclopramide (Jordan et al, 2004). It is known that the drug is never bound extensively to plasma proteins (approximately 30%). The whole body distribution volume is relatively high, approximately 3.5 L/kg, implying that there is always extensive drug distribution to the tissues (Naeimet al, 2008). ...
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and have chosen to specialize in neuropsychology and neuropsychopharmacology. However, in some states there are psychologists who are allowed to prescribe medication. Some psychological conditions are the result of bad experiences or bad habits that have formed in an individual.
Research Question Elderly people aged 65 and above are prone to various illnesses and conditions. In order to reduce the pain effects caused by illnesses or old age conditions, medics have come up with various drugs aimed at killing the pains. One of such drugs common among the elderly persons is benzodiazepine.
has been scientifically proven to be able to extend one’s life by four to six months, costing annually $54,000. Obviously, the cost of such a medication sometimes overshadows the fact that many people cannot afford such an expensive medication—as $54K
Drugs such as benzodiazepines when taken by elderly persons can be dangerous. However, it is worrying to note that many physicians continue to administer such drugs to elderly persons without interventions. Some of the common side effects associated with the drug
(John Hopkins, 2003) describes seven important elements of the patient-provider relationship. First is the communication, second is office experience, third is hospital experience, forth is education, fifth is integration, sixth is decision
Due to this, different strategies have been put in place to help patients with these disorders to regain their normal health functioning of the body. In this regard, behavioral treatment is one of the effective channels for patients with mental
It entails both study of physiological effects of drugs as well as the mechanisms of such action incorporating the correlation between the actions and effects within their chemical structures.
Should not be taken
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