This was necessary in order to ascertain the accuracy of data and help in statistical analysis. On the part of Kramer, et al. (2008), they adopted randomized or true experiment research design in their study. It had a double blinded trial with placebo controlled comparison between children aged below six years using acetaminophen and ibuprofen. In these two groups, the two medications were alternated with placebo in order to check whether there was a 0.6o C difference between the groups. The rationale for designing this study in this way was so as to check temperature differences between the two groups under study. As such, it was proper because they were checking on the efficacy of these two antipyretic drugs. Link between the Research purpose/question and Design There is a definite link between the research question and design in the study carried out by Britz, J. A., & Dunn, K. S. (2010). The aim of this study was to check on quality of life of patients with heart failure in relation to deficits that occasionally arise from healthcare provision. According to Newell & Burnard (2006), data that is used in any scientific study should be collected or based on parameters that are a reflection of the desired outcome. In this regard, the data was collected from three different sources which touched on quality of life. In order to make the design more elaborate, personal data of the patients such as age was also incorporated into the study. The same is true for the study undertaken by Kramer, et al. (2008) who were trying to find the efficacy of two antipyretic drugs. From practice, it is clear that these two drugs acetaminophen and ibuprofen are commonly used interchangeably by pediatricians to handle fever problems in children. However, there have been doubts about their efficacy when used together. To check on these doubts, it was necessary to use a controlled double placebo randomized study design. Intervention in Each Study There were no interventions in both the studies. The Independent and Dependent Variables In the study undertaken by Britz, J. A., & Dunn, K. S. (2010), the dependent variable is quality of life whereas the independent variables were specific self-care deficits. In this study, there was no blinding because it was a descriptive study that relied mostly on data from other sources. According to Newell & Burnard (2006), descriptive studies usually use data from other sources as opposed to data that is measured scientifically in a study. In this regard, the data were either obtained from the patients through questionnaires or from charts of patients. On the other hand, the study by Kramer, et al. (2008) had temperature as the dependent variables whereas efficacy of acetaminophen and ibuprofen was the independent variable. In this study, there was blinding on both groups under study since both of them were using the two drugs. In each group, the participants were supposed to be put on one of the drugs and placebo according to the required dosage prescribed. Each group was assigned a specific drug which was supposed to be administered alternating with the placebo. The pharmacist who administered the drugs to both the groups was not blinded and therefore knew what medication each group was being given and the schedule being followed. However, for the children, their parents and guardians were blinded as to which regimen was being administered to the subjects.