Gastroesophageal reflux Disease Gastroespohageal Reflux Disease (GERD) is a disease caused because of the reflux of the gastric contents into the lower portion of the esophagus. It is believed that GERD is primarily caused because of several reasons which increase the probability of moving the contents into the esophagus…
If the stomach motility is disturbed then it is possible that the contents would last their much longer and this would increase the bulk of the gastric contents which would reflux into the esophagus (Kumar et al 2005; Dore et al 2008). The reflux from the stomach can lead to esophagitis which means inflammation of the esophagus. The gastric juices entering the stomach can lead to an injury of the gastric mucosa of the esophagus and this leads to irritation in the esophagus. Most of the cases of GERD are primarily seen in children and the clinical features show heartburn, hematemesis or melena. The damage to the esophageal mucosa does not depend upon the symptoms of GERD but rather depend upon the time for which these symptoms have been occurring. If a reflux is not stopped for a long time then it is possible that much of the esophageal mucosa would be damaged. If the condition of GERD gets severe a person would face the problem of bleeding, ulcers, strictures and may possibly develop Barrett Esophagus (Kumar et al 2005; Hall & Guyton 2006). References KUMAR, V., ABBAS, A. K., FAUSTO, N., ROBBINS, S. L., & COTRAN, R. S. (2005). Robbins and Cotran pathologic basis of disease. Philadelphia, Elsevier Saunders. Hall, J. E., & Guyton, A. C. (2006). Guyton & Hall physiology review. Philadelphia: Elsevier Saunders. Top of Form Dore, M. ...
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(Gastroesophageal Reflux Disease Research Paper Example | Topics and Well Written Essays - 250 Words)
“Gastroesophageal Reflux Disease Research Paper Example | Topics and Well Written Essays - 250 Words”, n.d. https://studentshare.net/other/18851-gastroesophageal-reflux-disease.
Since its recognition, a notable quantity of research has been devoted to elucidating the pathogenesis of LPR, and establishing criteria and/or guidelines for the most relevant investigations and most effective management options.
However, there are still debates on the causal links between GERD and chronic cough, prompting the writing of this state of the science paper, which seeks to explore the already researched and published findings on the subject. Hopefully, the literatures and study findings reviewed will highlight the causal link between these conditions so that the management and treatment of infants, children, and adolescents with GERD and GERD-related chronic cough could be made more accessible and effective.
They are considered superior in their pharmacologic actions to other drugs used to treat peptic ulcers. The drug functions basically as an inhibitor of the proton pump. The drug carries out its action by diffusion into the parietal cells of the stomach. In the cells, they get converted into substances which act on the H+/K+ ATPase which forms an integral part of the pathway of the formation of the acid in the stomach.
The disorder has a high rate of incidence, and appears to be increasing in prevalence particularly in the western world. GERD is a multifactorial disease in which anatomical and functional factors combine to play a pathogenic role. The transient lower esophageal sphincter relaxation (TLESR) accounts for the majority of reflux episodes in patients with esophagitis and those with non-erosive reflux disease (NERD).The underlying causes are still incompletely known, of functional disorders such as increasing number of TLESR episodes perhaps in combination with impaired lower esophageal sphincter (LES) basal tone or with gastric or esophageal motor dysfunction.
Is there evidence to support a causal link between chronic cough and GERD in pediatric patients? 2. Has there been an increase in the prevalence of GERD in pediatric patients over the past 20-30 years, and if so, what are the proposed explanations? 3. Incidence of increased hospitalizations due to respiratory illness in pediatric patients with GERD?
These factors make lupus a very important topic for this course, as all students should gain a thorough awareness of the diseases that may be encountered during a professional career. Especially in the case of lupus, which is so complicated and has such a wide variety of possible symptoms, the student must take extra care to examine the characteristics of the disease.
Of the two, primary reflux is the most common. It is as a result of an incompetent ureterovesical tunnel.
Under normal circumstances, the ureter passes through the detrusor muscle and ends at the ureteral hiatus
Cough is the most common symptom for which patients seek medical attention. In adults, cough variant asthma, postnasal drip or rhinosinusitis are the most common causes of chronic cough in Western countries. A positive association between cough and weakly acidic reflux was found in a significant subgroup of patients with unexplained chronic cough.
When food is eaten, it passes through the esophagus into the stomach, from the throat. Muscle fibers ring prevents the back movement of swallowed food in the lower esophagus (Gary, 2008). When the muscle ring doesn’t close, the contents can leak into the
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