Protein Families - Coursework Example

Only on StudentShare

Extract of sample
Protein Families

The analysis of a single gene sequence is done by establishing similarity with other known genes, determining phylogenetic trees and evolutionary relationships; identifying well-defined domains in the sequence, identifying physical properties, binding sites and modification sites comprising of the protein sequence features.
For analysis of complete genomes and to determine which gene families are present in the protein and which are not present, several techniques such as location of genes on the chromosomes, correlation with function or evolution, expansion of duplication of gene families, identification of missing enzymes, and presence or absence of biochemical pathways are considered. Large scale events that have affected the evolution of organisms are also studied for genome analysis.
When genes or genomes are analyzed with respect to functional data the techniques used are expression analysis, micro array data, mRNA concentration measurements, protein concentration measurements, proteomics, and covalent modifications. For analysis of gene and genomes from a functional perspective, comparative analyses of biochemical pathways are made along with deletion or mutant genotypes vs. phenotypes and identification of essential genes, or genes involved in specific processes in structure and functions of the organisms.
Analysis of protein structure and functions are done with the help of computer simulations which are used as tools to investigate protein structure and dynamics under a wide variety of conditions. ...
Download paper

Summary

The paper deals with the analysis of protein families using bioinformatics programs such as Crescendo/CHARMM/Amber etc. Reportedly, the general protein analysis involves
the development of methods to predict structure and function of proteins.
Author : spacocha

Related Essays

C-reactive protein as a novel biomarker
This process leads to the formation of foamy macrophages and atheromatous plaques and, finally, to atherothrombotic disease. Atherosclerosis is associated with high morbidity and mortality.…
8 pages (2008 words) Essay
Folding and Aggregation
The three dimensional structures of proteins aid in delineating protein functions at a molecular level and the structure of proteins are determined usually with X ray crystallography, NMR spectroscopy etc. Some structural features of proteins would be necessary to perform certain biochemical functions although multifunctional and structural proteins may have higher number of residues than the average of 300 residues. Large aggregates are formed as a result of folding from protein subunits and actin molecules also assemble into actin filaments.…
4 pages (1004 words) Essay
Protein Concentration
The two most common examples are -helix and -sheet (fig. 1)…
4 pages (1004 words) Lab Report
Protein Translocation
This also helps in identifying novel components for particular specific pathways and components common for all pathways. Mitochondrial proteins tend to be nuclear encoded and these proteins must be translocated to the compartments within the mitochondria (Copley, 1997; Berg 2002). The final localisation is determined with interaction of nascent polypeptides with inner and outer membrane translocation complexes.…
4 pages (1004 words) Essay
Single Cell Protein
Although, there is a global shortage of protein, the shortage is in developing countries which cannot afford this technology.…
4 pages (1004 words) Essay
Got a tricky question? Receive an answer from students like you! Try us!