Clocks in the Vasculature

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Research has discovered autonomous biological clocks in cells which operate at the cellular, genetic, and molecular levels and hence at organic levels. They function together in order to optimise the efficiencies of biological systems through temporal synchronisation of physiological actions and behaviour.


An example is mammalian sleep rhythm or hunger, and its is now well known that there is a light-controlled master clock in the brain that controls these activities. Now the research is exploring the molecular mechanisms of these clocks in the peripheral tissues, which have been postulated to work through nutrient availability, although the exact mechanism is not known.
heart which is essentially vascular tissue. This activity physiologically is autonomous, originating in the neurocardiac muscles of the heart and in health, occurs 72 times per minute in a regular fashion. In most and usual cases, human beings cannot control the frequency of these beats on their own. However, several neurophysiological conditions can cause change in this pattern and there is established roles of emotion, feelings, strenuous activities, stress in destabilizing this clock either to a higher or a lower rate, and there are physiological systems that tends to bring back these abnormal rates to normal through neural and humoral mechanisms.
Small molecules interact with molecular hormone receptors module circadian rhythm. ...
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