Amino Acide

Masters
Essay
Science
Pages 7 (1757 words)
Download 0
Production of peptides in known as "peptide synthesis", in organic chemistry. However, these organic compounds contain multiple amino acids which are bound together via "peptide" bonds; also known as amide bonds. Synthesis of peptides involves the coupling of carboxyl group or C-terminus of one amino acid to the amino group or N-terminus of another amino acid…

Introduction

Polymerization is a common reaction, due to excessive use of amino acids to ensure coupling during each synthesis phase. As a result, a series of deprotection phases are added to the synthesis process which takes the following form:
t- Boc protecting group: This group requires more number of acid stable groups for side chain protection in orthogonal strategies. It was most commonly used to protect the terminal amine of the peptide being synthesized. This group can be added to amino acids with t-Boc anhydride and a suitable base. It reduces aggregation of peptides during synthesis.[1][11]
Fmoc protecting group: It is currently being most widely used in the iterative synthesis of a peptide from amino acid units. It is usually removed from the N-terminus of the peptide during iterative synthesis. It is also cleaved under very mild basic conditions and is stable under acidic conditions. Fmoc group is preferred over BOC due to ease of cleavage, but it is less atom-economical.
Nucleoside analogs are replications of natural nucleosides. They prevent the production of new virus, when incorporated into virus DNA or RNA, during virus replication. The nucleoside analogues replace the natural nucleosides to block the completion of the viral DNA chain when they infect a new cell by HIV. ...
Download paper
Not exactly what you need?

Related papers

Amino Acide
Polymerization is a common reaction, due to excessive use of amino acids to ensure coupling during each synthesis phase. As a result, a series of deprotection phases are added to the synthesis process which takes the following form:…
Biological molecules
The two strands of the helix run in opposite directions (1 "up" and 1 "down"). The inner edges of the helices are formed by the nitrogenous bases and they run in pairs. Adenine pairs with thymine with 2 hydrogen bonds and cytosine pairs with guanine with 3 hydrogen bonds (Murray et al, 2007).…
Folding and Aggregation
The three dimensional structures of proteins aid in delineating protein functions at a molecular level and the structure of proteins are determined usually with X ray crystallography, NMR spectroscopy etc. Some structural features of proteins would be necessary to perform certain biochemical functions although multifunctional and structural proteins may have higher number of residues than the…
Protein Translocation
This also helps in identifying novel components for particular specific pathways and components common for all pathways. Mitochondrial proteins tend to be nuclear encoded and these proteins must be translocated to the compartments within the mitochondria (Copley, 1997; Berg 2002). The final localisation is determined with interaction of nascent polypeptides with inner and outer membrane…
Biological Module
The relationship lead to the permanent association and integration leading to eventual evolution of eukaryotes.…
Biochemistry Master Essay
Breast cancer, as well as ovarian cancer, is a large problem of medicine and both are life treating, especially for women. These cancers are of particular importance because they are promoted by estrogen. In 2000, approximately 130,000 women died of breast cancer; nearly two thirds of these women were postmenopausal. In pre-menopausal women estrogen is produced in the ovaries, so reducing estrogen…
Treatment of Unipolar Depression
Overall, 5-HTP appeared to be slightly better tolerated than fluvoxamine, although the results did not reach the level of statistical significance.…