Until now, the focal area of endocrine disruption has been on the chemicals that mimic oestrogens (xenoestrogens). But, the recent proof suggests that quite a number of abnormalities in the human breast could be interceded by means of the androgen receptor.
The main identified risk factor remains lifetime exposure to oestrogen. In view of the involvement of oestrogen in the development, progression and treatment of breast cancer, questions have to be asked concerning potential interactions of the many chemicals in the environment which can be stored in breast tissues and which can mimic the action of oestrogen. The source of such compounds can be dietary, from plants (phytoestrogens) or from environmental contaminants of food/water (xenoestrogens) but I have proposed that an alternative route for exposure may be through the long-term regular application to the underarm of a variety of cosmetic ingredients with oestrogenic activity.
The molecular basis of oestrogen action involves the interaction of the oestrogenic ligand with intracellular oestrogen receptors, ER' and ER', which function as ligand-activated transcription factors to alter the expression patterns of hundreds of genes and to regulate growth of human breast cancer cells. ...Show more