With man's present need to acquire significant instruments for the effective asymmetric synthesis of compound organic molecules, the study of catalytic asymmetric synthesis has become an important aspect of organic chemistry. Generally, popular catalysts which are usually used by organic chemists utilize transition metals in order to trigger a chemical reaction in the presence of a chiral ligand (Noyori, 1994.)
Hence, it is undeniably interesting to study the catalytic asymmetric synthesis of cinchona alkaloids , which have also been helpful in man's daily living. This includes its role in the production of food flavorings and medicines for different ailments like malaria.
Additionally, the popularity of cinchona alkaloids over the years is also because of its qualifications in the three primary criteria of catalysts, which are as follows: 1) the diversity of reactions that the catalyst can trigger; 2) the accessibility of both enantiomeric antipodes of the catalyst at an affordable cost; and 3) the stability of the catalyst.
The research aims to study the catalytic asymmetric synthesis of the popular two pairs of cinchona alkaloids which are enantiomeric in nature: cinchonine and cinchonidine, and; quinine and quinidine. The researcher aims to study the two pairs by isolating them through extraction of the bark of the cinchona tree; a native of tropical regions. Due to their widespread use, all four members are readily available in large quantities from most chemical suppliers.
Furthermore, before conducting several experiments for the research, the researcher will gather enough materials documenting the history of cinchona alkaloids. ...