StudentShare solutions
Triangle menu

Biochemistry Master - Essay Example

Nobody downloaded yet

Extract of sample
Biochemistry Master

Breast cancer, as well as ovarian cancer, is a large problem of medicine and both are life treating, especially for women. These cancers are of particular importance because they are promoted by estrogen. In 2000, approximately 130,000 women died of breast cancer; nearly two thirds of these women were postmenopausal. In pre-menopausal women estrogen is produced in the ovaries, so reducing estrogen from other sources it not important, but in post menopausal women most of the estrogen in the body is produced in the adrenal gland from conversion of androgens and also from adipose tissue through special enzyme called aromatase. The large influence of the estrogen produced outside the ovaries by aromatization is clear. In postmenopausal women, their estrogen comes from the actions of atomatase-final step in the pathway of estrogen biosynthesis by creating an aromating ring in the steroid molecule, and so its inhibitor may be used to treat estrogen tumors, and so, effective treatment in breast cancer is aromatase inhibitor. Also, it is used in women when their ovaries are no longer producing estrogen. It is not the same in premenopausal women or the opposite effects appear, the main estrogen comes up from ovaries, not by conversion androgen to estrogen, so blocking aromatization effects does not increase the androgen production.
According to clinical researches, a correlation has been establishes between estrogen receptors and the growth of breast cancer and so effective therapy can be made by aromatase inhibitor working more efficient then tamoxifen. The hormone estrogen delivers growth thru signals to the hormone receptors, so less estrogen in the body leads to fewer growth signals and stopping the growth of cancer. Now medical experts consider aromatase inhibitor for postmenopausal women with invasive hormone receptor positive for breast cancer, in early and advanced stage.
Aromatase inhibitor, according to research, can stimulate ovulation- can treat infertility. According to 65 patients included in the studies, drugs can suppress estrogen production in endometriosis, and reduces pain and chance of endometriosis in combination with hormonal treatment. It is significant to mention that there should be no long-term use because it may cause bone loss. It also helps bodybuilders, who take anabolic steroids from being converted to estrogen such as in the case of gynecomastia. In one recent study, however, aromatase inhibitors were found to be no more successful at treating pubertal gynecomastia than a placebo. Aromatase inhibitors have also been shown to reverse age-related declines in testosterone, as well as primary hypogonadism.
The third generation drugs: anastrozole, letrozole and exemestane has given remarkable specificity and potency. Leading thru initial results from clinical trials, these agents will become the cornerstones of future endocrine therapy as a successful rational drug. It is important that the aromatase inhibitor have additional benefits thru pleiotropic effects as a particular role in preventing cancer or treating benign conditions.

Xantine oxidase, a form of enzyme xantine oxidoreductase, is molybdoprotein containing flavoprotein and consists of two subunits of approximately 145 KDa. Generally, it occurs in vivo as an NAD depended cytosolic dehidrogenase enzyme. It can oxidize NADH ...Show more

Summary

Aromatase inhibitor represent a class of antiestrogens, a drug that inhibits the enzyme aromatase by lowering the level of estrogen estradiol ,by process called aromatization. There are two types: first one is irreversible steroidal inhibitor and the second one is non-steroidal inhibitor such as anatrazole which inhibits the enzymes by reversible competition…
Author : alaynawest
Biochemistry Master Essay essay example
Read Text Preview
Save Your Time for More Important Things
Let us write or edit the essay on your topic
"Biochemistry Master Essay"
with a personal 20% discount.
Grab the best paper

Check these samples - they also fit your topic

The challenges of finding talent in pharmaceutical MNEs
Remain competitive in a turbulent business environment is the key success mantra for any business. Odonez de Pablos (2004) raised a valid question that whether we are heading towards a business environment where supply of human resource is plenty but presence of talented human resource is very less in comparison to labour market demand.
19 pages (4750 words) Essay
Income taxition law
Capital gains result from selling assets such as real estates and shares. Business goodwill also results into capital gains. There is no distinction between income on revenue account, which is referred to as business income and income on capital account, which is referred to as capital income.
12 pages (3000 words) Essay
Leadership Master Essay
Fred Fiedler developed the first contingency model for leadership, known as The Fiedler contingency model. It is suggested the model is "the most comprehensive programme of research ever conducted on leadership" (Fiedler, 1967, as cited in Elkin and Inkson, 2000, p.
8 pages (2000 words) Essay
Medical Biochemistry Essay
Based on the changes in dietary patterns of individuals, in a normal healthy body glucose production by the liver is regulated and so is the case with the uptake of glucose by the muscles and other tissues. The two crucial mediators in this regulatory process are insulin and glucagon.
8 pages (2000 words) Essay
Nursing Practice Master Essay
The third is that cnceptual cmpartmentalizatin in science ften leads t a dissciatin with the previus wrk in the field. These things are cnsidered f scientific relevance t the develpment f high quality nursing service. The impetus fr this paper was the idea that the cncept f evidence-based nursing represents smething f a paradx.
8 pages (2000 words) Essay
Biochemistry Essay
Reduced oxygen consumption was observed when mitochondria were incubated with linoleoyl CoA and carnitine. The patient's blood levels of carnitine are lower than normal and an acylcarnitine derivative is present in blood and urine. Mass spectrometry analysis of urine identifies this acylcarnitine derivative as trans- 2-cis-4-decadienoyl-carnitine.
5 pages (1250 words) Essay
Market Research Master Essay
And, in the age of the information revolution, the quality of strategic decision-making is greatly influenced by the quality of information available for analysis and appropriate decision-making. The need for quality information, needless to say, suggests the significance of marketing research in strategic marketing decision-making and in ensuring business success, particularly so in the present business environments characterised by the pressures of global competition and fast paced changes in information and communication technologies as well as constantly evolving marketplaces and consumer choices.
10 pages (2500 words) Essay
Internet And Biotech: Two Professors Take On Two Phenomena
Kaushik Rajan and Tiziana Terranova are university professors who have made observations about the human genome and the internet respectively. In Bio Capital: the Constitution of Postgenomic Life, Rajan explains how the human genome pro- ject developed and what its implications are for society.
13 pages (3250 words) Essay
Clinical Biochemistry Essay Short questions(degree)
Hyperglycemia, wasting of muscles due to increased protein metabolism and facial edema due to increased steroids is seen. Tumors of the anterior pituitary can lead to increased
2 pages (500 words) Essay
Clinical Biochemistry Essay Questions
Levels of thyroxine, triiodothyronine and thyroid stimulating hormones are checked basically for hyper and hypo thryroidism. The basal metabolic rate is also determined because it increases greatly in hyperthyroidism whereas in hypothyroidism it is reduced.
2 pages (500 words) Essay
Hire a pro to write
a paper under your requirements!
Win a special DISCOUNT!
Put in your e-mail and click the button with your lucky finger
Your email
YOUR PRIZE:
Apply my DISCOUNT
Comments (0)
Click to create a comment
Contact Us