Biochemistry Master Essay

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Aromatase inhibitor represent a class of antiestrogens, a drug that inhibits the enzyme aromatase by lowering the level of estrogen estradiol ,by process called aromatization. There are two types: first one is irreversible steroidal inhibitor and the second one is non-steroidal inhibitor such as anatrazole which inhibits the enzymes by reversible competition.


Breast cancer, as well as ovarian cancer, is a large problem of medicine and both are life treating, especially for women. These cancers are of particular importance because they are promoted by estrogen. In 2000, approximately 130,000 women died of breast cancer; nearly two thirds of these women were postmenopausal. In pre-menopausal women estrogen is produced in the ovaries, so reducing estrogen from other sources it not important, but in post menopausal women most of the estrogen in the body is produced in the adrenal gland from conversion of androgens and also from adipose tissue through special enzyme called aromatase. The large influence of the estrogen produced outside the ovaries by aromatization is clear. In postmenopausal women, their estrogen comes from the actions of atomatase-final step in the pathway of estrogen biosynthesis by creating an aromating ring in the steroid molecule, and so its inhibitor may be used to treat estrogen tumors, and so, effective treatment in breast cancer is aromatase inhibitor. Also, it is used in women when their ovaries are no longer producing estrogen. ...
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