StudentShare solutions
Triangle menu

Phosphoribosylpyrophosphate Synthetase - Essay Example

Nobody downloaded yet
Others require an additional chemical component called a cofactor such as an inorganic ion Fe2+, Mg2+, Zn2+ or a metalloorganic molecule called a coenzyme. (Lehninger 4th Edition)
Enzymes are classified into six classes each with sub classes based on the type of reaction catalyzed. Thus our enzyme of interest Phosphoribosylpyrophosphate (PRPP) Synthetase (Prs) belongs to the class Transferases catalyzing group transfer reactions with its Enzyme Commission Number as 2.7.6.1. (Online Mendelian Inheritance in Man, 2010)
Phosphoribosylpyrophosphate synthetase (Prs) (or Ribose-phosphate diphosphokinase) catalyses the synthesis of phosphoribosyl pyrophosphate (PRPP), an intermediate in nucleotide metabolism for the de novo and salvage pathways of purine and pyrimidine biosynthesis and the biosynthesis of the amino acids histidine and tryptophan.
One of the important specialized pathways of a number of amino acids is the synthesis of purine and pyrimidine nucleotides. The two ringed purine members Adenine, Guanine, Hypoxanthine and Xanthine and the single ringed pyrimidines namely Cytosine, Thymine, Uracil are important for a number of reasons. Most of them, not just ATP, are the sources of energy that drive most of our reactions. ATP is the most commonly used source but GTP is used in protein synthesis as well as a few other reactions. UTP is the source of energy for activating glucose and galactose. CTP is an energy source in lipid metabolism. AMP is part of the structure of some of the coenzymes like NAD and Coenzyme A. We can both synthesize them de novo and salvage and reuse those we already have.(Angstadt 1997)
Metabolic contribution of PRPP to the purine biosynthesis and other anabolic pathways

Source: Taken and Adapted from BMC Biotechnology (Jimenez 2008)
PRPP, synthesized from ribose-5-phosphate and ATP, is therefore a key compound for purine biosynthesis, and it is also an important cellular metabolite because it represents a link between carbon and nitrogen metabolism. PRPP is a biosynthetic precursor of histidine and tryptophan, and it is also required for the de novo and salvage pathways of purine, pyrimidine and pyridine (NAD+, NADP+) nucleotides. It has been calculated that approximately 80% of the metabolic flux through PRPP is directed to purine and pyrimidine synthesis
The formation of PRPP is catalyzed by the enzyme PRPP synthetase which is encoded by PRS genes

Pathway of Purine nucleotide synthesis and its regulation by PRPP. Taken and adapted from (Becker, Kim et al. 1992)
The PRPP is further committed to de novo purine nucleotide synthesis in a 10 step enzymatic reaction as follows:

Taken From Rolfes 2006
This essay will examine the reactions that take place during the PRPP pathways and the synthesis of purine nucleotide. In microbes such as Escherichia coli and Saccharomyces cerevisiae, the inability to biosynthesize purine nucleotides leads to auxotrophy. In Drosophila, purine nucleotide synthesis is required for development and metamorphosis. In plants such as Arabidopsis and tobacco (Nicotiana tabacum), synthesis of nucleotides is developmentally regulated, whereas in the tropical legumes it plays an additional important role in nitrogen storag. In humans, disorders in the purine nucleotide biosynthetic and salvage pathways have devastating consequences, leading to disorders such as SCIDS (severe combined immunodeficiency syndrome), ...Show more
Cite this document
  • APA
  • MLA
  • CHICAGO
(“Phosphoribosylpyrophosphate Synthetase Essay Example | Topics and Well Written Essays - 3750 words”, n.d.)
Retrieved from https://studentshare.net/science/304875-phosphoribosylpyrophosphate-synthetase
(Phosphoribosylpyrophosphate Synthetase Essay Example | Topics and Well Written Essays - 3750 Words)
https://studentshare.net/science/304875-phosphoribosylpyrophosphate-synthetase.
“Phosphoribosylpyrophosphate Synthetase Essay Example | Topics and Well Written Essays - 3750 Words”, n.d. https://studentshare.net/science/304875-phosphoribosylpyrophosphate-synthetase.
  • Cited: 0 times

Summary

In the 1850s, Louis Pasteur concluded that fermentation of sugar into alcohol by yeast is catalyzed by "ferments". Then in 1897 Eduard Buchner discovered that yeast extracts could ferment sugar to alcohol providing that fermentation was performed by molecules which continued to function when removed from cells…
Phosphoribosylpyrophosphate Synthetase
Read Text Preview
Save Your Time for More Important Things
Let us write or edit the essay on your topic
"Phosphoribosylpyrophosphate Synthetase"
with a personal 20% discount.
Grab the best paper

Check these samples - they also fit your topic

Investigation of Human Disease
Functionally, it synthesizes substances of almost all clotting factors necessary in coagulation process. Meanwhile, vitamin K, which is synthesized in the intestine by bacteria, is also necessary for hepatic synthesis of prothrombin, serum prothrombin conversion accelerator or factor VII, plasma thromboplastin component or factor IX, factor X, and protein C.
6 pages (1500 words) Essay
High Protein Diets: Metabolic Poison for those with Inborn Errors of Amino Acid Metabolism
Inborn errors of metabolism are hereditary diseases in which the cellular metabolism is abnormal due to an inherited defect in an enzyme. Inborn errors of metabolism usually manifest in the neonate or an infant but can even be first seen in an adult. Abnormalities in the production or metabolism of proteins, carbohydrates etc are usually due to a single gene defect.
8 pages (2000 words) Essay
Pathobiology (case study)
However, the disease is asymptomatic in some patients, making it hard to detect until the late stages, and by then the patient would be subjected to invasive procedures. To prevent the rapid advancement of malignant tumour growth, tissue samples and methods of identifying cancerous liver cells are employed when masses or lesions are detected in patients that had a prior history of colorectal cancer (Goodman, 2007).
6 pages (1500 words) Essay
Photosynthesis and Cellular Respiration
While photosynthesis uses solar energy directly and stores it within chemical bonds cellular respiration releases this stored energy and makes it available to the plant when it needs the energy. That photosynthesis precedes cellular respiration is not surprising.
5 pages (1250 words) Essay
Treatment of Postmenopausal Osteoporosis
4 pages (1000 words) Essay
Biochemistry
The above mentioned symptoms correlate with the disorder 'Glycogen storage disease type IV', also known as "Andersen's disease". It is a rare disease that leads to early death. Glucose, a source of energy, is stored in the liver and muscle in the form of its polymer, glycogen.
8 pages (2000 words) Essay
A Comparison between the Mechanisms of Action of Hormone Replacement Therapy and Selective Estrogen Receptor Modulators in the Treatment of Postmenopausal Osteoporosis
Bone remodeling is a process that occurs throughout life. There are two types of cells in bone, osteoblasts and osteoclasts. In health, there is a balance between bone resorbing osteoclasts and bone depositing osteoblasts.
4 pages (1000 words) Essay
Does urea formation have a feedback inhibition mechanism Explain the why or why not
mals, arginine is not synthesized for protein synthesis because of “inborn errors of urea cycle enzymes” (Das 475), and it is produced with processes other than feedback mechanism. There is no feedback inhibition mechanism exhibited by urea formation during urea cycle, at
1 pages (250 words) Essay
Antimicrobial Agents in Microbiology
This method usually is reserved for non-living objects, as sterilizing involves harsh procedures that can’t be applied to living bodies. Sterilized products involve syringes, surgical instruments, and commercially packed up foods are crucial to the well
3 pages (750 words) Essay
Comments (0)
Click to create a comment
Let us find you another Essay on topic Phosphoribosylpyrophosphate Synthetase for FREE!
Contact us:
+16312120006
Contact Us Now
FREE Mobile Apps:
  • About StudentShare
  • Testimonials
  • FAQ
  • Blog
  • Free Essays
  • New Essays
  • Essays
  • The Newest Essay Topics
  • Index samples by all dates
Join us:
Contact Us