StudentShare solutions
Triangle menu
We use cookies to create the best experience for you. Keep on browsing if you are OK with that, or find out how to manage cookies.

Drug Dose and Its Concentration at Receptors - Essay Example

Nobody downloaded yet

Extract of sample
Drug Dose and Its Concentration at Receptors

These factors are discussed in more detail below, based on the description of Goodman, et al. (2011, ch. 2). The characteristics of the drug molecule itself that affect the drug’s concentration at the receptor site include its molecular size, degree of ionization, lipid solubility, and its affinity for serum and tissue proteins. The plasma membrane (of skin or intestinal cells, for example) is a common barrier to drug distribution; drugs that are not lipid soluble will not be able to permeate the membrane and not reach the target site. A drug of small molecular size will travel more easily through the membranes than a larger molecule, reaching the target in higher concentrations. Ionized molecules, and those that bind to proteins, also have difficulties in passing through the membrane. If the drug has a tendency to ionize at the pH of the intestinal lumen or the blood, the ionized form will have difficulty passing through lipid plasma membranes. If the drug interacts with transporter proteins on the cell membrane, its uptake into the cell may be increased or decreased, depending on the direction in which the transporter moves the drug. For example, the P-glycoprotein in enterocytes limits the oral absorption of some cancer chemotherapeutic agents by exporting them back into the lumen of the GI tract. Similarly, it has been found that multidrug transporters such as P-glycoprotein (PGP) and members of the multidrug resistance-associated protein (MRP) family are over-expressed in capillary endothelial cells in epileptogenic brain tissue, and, by transporting anti-epileptic drugs out, these proteins may be responsible for the pharmacoresistance of the epileptic brain to anti-epileptic drugs (Löscher and Potschka, 2002). ...Show more
Cite this document
  • APA
  • MLA
  • CHICAGO
(“Drug Dose and Its Concentration at Receptors Essay - 1”, n.d.)
Retrieved from https://studentshare.net/social-science/452453-explain-how-the-relationship-between-the-dose-of-drug-given-to-an-individual-and-the-concentration-of-drug-molecules
(Drug Dose and Its Concentration at Receptors Essay - 1)
https://studentshare.net/social-science/452453-explain-how-the-relationship-between-the-dose-of-drug-given-to-an-individual-and-the-concentration-of-drug-molecules.
“Drug Dose and Its Concentration at Receptors Essay - 1”, n.d. https://studentshare.net/social-science/452453-explain-how-the-relationship-between-the-dose-of-drug-given-to-an-individual-and-the-concentration-of-drug-molecules.
  • Cited: 0 times

Summary

The paper “Drug Dose and Its Concentration at Receptors” will discuss ‘bioavailability’, which refers to the fraction of the dose of the drug given that reaches its site of action. The characteristics of the drug molecule itself include degree of ionization…
Drug Dose and Its Concentration at Receptors
Read Text Preview
Save Your Time for More Important Things
Let us write or edit the essay on your topic
"Drug Dose and Its Concentration at Receptors"
with a personal 20% discount.
Grab the best paper

Check these samples - they also fit your topic

Explain how the relationship between the dose of drug given to an individual and the concentration of drug molecules
According to Goodman, et al. (2011, ch. 2), pharmacokinetics divides this journey into the stages of absorption and distribution. The term ‘bioavailability’ refers to the fraction of the dose of the drug given that reaches its site of action. Various characteristics of the drug molecule, the method of administration of the drug used, the route of the drug before it reaches the target receptor, the interactions between the drug molecule and body tissues other than the target, and the nature of the organ where the target receptor is located, all affect the bioavailability.
4 pages (1000 words) Essay
Health Insurance Concentration and its Consequences
One of the major causes for the rise in insurance cost includes the health care concentration. This not only affects the cost of insurance, but also affects the effectiveness and admittance to health care in the country. How/ where do Americans get health insurance?
8 pages (2000 words) Research Paper
Brain neuronal Cb2 cannabinoid receptors in drug abuse and depression
Many humans go through high relapse cases and reoccurrence of the cases even after they undergo treatment. Laboratory detecting procedure does not show the presence of cannabinoid CB2 receptors (CB2-Rs) in a healthy brain. The demonstration in rats indicates the presence of CB2-R in microglia and other cells linked to inflammation.
5 pages (1250 words) Assignment
Protein Concentration
With respect to their structure, biochemists often refer to four different aspects: Secondary structure, local interactions held together by hydrogen bonds between the lone pair of electrons of an oxygen atom and the hydrogen attached to a nitrogen atom.
4 pages (1000 words) Lab Report
Concentration camp
As well, camps were used as special use camps such as brothels, armament building camps, hostage camps, and camps designed for
5 pages (1250 words) Essay
Genentech's move to restrict the use of its drug Avastin, its Cancer Drug, by ophthalmologists on Eye
An analysis will uncover the issues on Genentech’s apparent financial interest against the public interest in obtaining an efficient but more cost-effective alternative to Lucentis. Although there is success in revoking the previous decision of
5 pages (1250 words) Essay
Latin Americas guerrilla groups, its drug gangs and poverty
ies of Latin America during the 80’s and 90’s was evident from the stature of all fields of economic and social development which include infrastructure, education, labor market and healthcare. As a result a large population of the poor people in Latin American countries is
3 pages (750 words) Essay
Drug profile
CFC-free oral free inhalers are available as Asmol CFC-free, Ventolin CFC-Free, Airomir and AiromirAutohaler (with breath actuated device), and APO
8 pages (2000 words) Essay
Soil concentration
Cac2+ is an important mineral nutrient in soil for plant life, but is harmful if in excess. The main cause of soil salinity can be attributed to the water management practices used on a given soil
1 pages (250 words) Essay
Protein concentration
2013). Proteins are the basis of living tissues. They are made up of amino acids coded by the genes. They are multi-performing substances for various biological processes such transport of oxygen, transmit cellular messages, and catalyze body reactions and many
4 pages (1000 words) Essay
Comments (0)
Click to create a comment
Let us find you another Essay on topic Drug Dose and Its Concentration at Receptors for FREE!
Contact us:
+16312120006
Contact Us Now
FREE Mobile Apps:
  • About StudentShare
  • Testimonials
  • FAQ
  • Blog
  • Free Essays
  • New Essays
  • Essays
  • The Newest Essay Topics
  • Index samples by all dates
Join us:
Contact Us