Drug Study Paper

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Pharmacological Management of Congestive Heart Failure Using Captopril and Its Therapeutic Implications Abstract This paper ventured to describe and critically examine the pharmacological management of congestive heart failure (CHF) using Captropril an angiotensin-converting enzyme (ACE) inhibitor class of anti-hypertensive drugs.


The readings also showed that the pharmacological management of CHF may be typified into first line and second line agents. The first line agents consist mainly of ACE-I, diuretics and beta blockers, while the second line agents consists of digoxin and hydralazine-isosorbide dinitrate. Captropil belongs to the second line of pharmacological agents. Use of Captropil had been found to enhance cardiac performance, among others. However, ACE inhibitors like Captropil sometimes causes in amigo-edema, painful tongue ulcers, and alveoli is to name a few. The implications of these and the rest of the findings are discussed in the conclusion. Discussion Congestive heart failure Congestive heart failure (CHF) is defined as an inability of the heart in supplying normal oxygen and nutrient demands to the body. CHF can be caused by a number of diseases which: (1) weaken the cardiac muscle; (2) harden the cardiac muscle; and (3) increase tissue oxygen demand beyond the capacity of the heart. This condition occurs primarily on elderly patients (Kaufman et al., 2008). Congestive heart failure commonly results from a dysfunctional heart muscle or myocardial dysfunction. CHF may also result from changes in the structure and function of the heart medically termed as progressive cardiac remodeling (Medifocus, 2011). ...
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