Multidrug Resistance in Mycobacterium Tuberculosis

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Despite advances in different fields of Medicine and drastic improvements in diagnostic technological know-how, the diagnosis and management of tuberculosis remain elusive. …

Introduction

Thus, the world is threatened with the risk of multi-drug resistant tuberculosis in the form of a pandemic that thrusts on the financial state of the State. Apart from that, emergence of immune deficiency viral disease has also predisposed to rapid spread of multi-drug resistant tuberculosis. Present knowledge on the molecular basis of development of multi-drug resistance may be utilized to develop a diagnostic protocol applying improved genetic analysis to detect the point mutations in the multi-drug resistant strains of Mycobacterium tuberculosis, so the clinicians may diagnose and treat this disease better. This research proposal aims to analyze the scientific basis of such a protocol, not only to add to the existing knowledge but also to devise a method that at least theoretically has far-reaching implications in the control of the disease that could be a global threat.

Background: Recent years have witnessed a phenomenal upsurge in number of reported cases of multi-drug resistant Mycobacterium tuberculosis (MDR-TB) infection. Multi-drug resistant tuberculosis is defined as bacterial isolate strains that are resistant to both isoniazid and rifampin with or without resistance to other anti-tuberculosis drugs. Since there is a gradual increase in the number of cases throughout the world including the developed countries, World Health Organization (WHO) has termed this as a global emergency. The rise of MDR-TB showing resistance to conventional treatments is a serious threat to control of tuberculosis disease load throughout the world in high-prevalence countries and low prevalence countries as well. ...
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