Administration of estrogen and progesterone by means of oral, transdermal or depot injection methods inhibits ovulation by the process of negative feedback inhibition. These hormones exert their action by inhibiting the secretion of gonadotrophins like lueteinizing hormone (LH)…
Pills containing progesterone also act by secreting thick cervical mucus which blocks the movement of the sperm beyond the cervix. There are many different types of progesterones like synthetic or oral progesterone, crinone, injectible progesterone and progesterone suppositories. Before recommending an oral contraceptive pill which is usually a combined oral contraceptive pill (COCP) to the client, a detailed clinical history must be taken. The history should cover information like the previous and current medications taken by the client, herbal and over the counter remedies and drug usage. In case of women above 35 years and women with a history of cardiovascular disease, diabetes, migraines, gall bladder disease and pulmonary hypertension, COCP recommendation should be avoided (Petitti, 2003).
The oral contraceptive may either be a combination birth control pill or a minipill. The combination birth control pill contains both progestin and estrogen and different combinations of active and inactive pills which may be conventional or continuous dosing type. Progestin is the only constituent of the minipill. The combination birth control pills may be monophasic or triphasic. In case of a monophasic birth control pill, every active pill comprises of the same quantity of progestin and estrogen, whereas the triphasic combination birth control pill contains three different types of pills that contain different hormones taken for a period of 3 weeks. Other than oral contraceptives, there are also novel approaches available to prevent conception. Ortho evra is a trans-dermal patch that is worn on any region of the body like abdomen, buttocks, upper arm or upper torso except the breasts that delivers progestin and estrogen in an uninterrupted manner into the blood stream through the skin. Contraception is also achieved through depot specific injections. For instance, Depo provera is medroxyprogesterone acetate which could ...
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The purpose of this research is to investigate the following: drugs from natural sources; plants as a source of drugs ; microorganism drug sources; uses of natural products in drugs; drug design by computer modeling and strengths of computer modeling in drug design. The computer modeling in drug design holds a massive potential for the pharmaceutical industry
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In their article “Progesterone as a neuroprotective factor in traumatic and ischemic brain injury” published in Progress in Brain Research, they posited that the search for a single receptor for cure of stroke and traumatic brain injury has not been successful due to the complicated pathophysiology mechanism the neuronal injuries induce.
No inhalation of the spray should take place. An initial one-metered dose ought to be sprayed below the tongue at an attack’s onset, followed by another metered dose within a period of five minutes should pain relief not occur. It is recommended that it should not exceed two metered doses.
Absorption of the drug is dependent upon the dose total, duration of exposure, concentration of the dose and the site of exposure (Kwan, 2001). The drug absorbed well in the gastrointestinal system but undergoes extensive first pass hepatic transformation.
(6 marks) Body System Parasympathetic Activation Sympathetic Activation Clinical Symptom / Condition e.g.Heart - Rate Decreased heart rate Increased heart rate Bradycardia Heart – Force of Contraction Decreases cardiac contraction Increases the force of contraction Cardio vascular disorders like distorted cardiac rhythm Pupil Constricts the iris muscles to allow little light to pass to the pupil (Shiota and Kalat, 2012, p.
tural configuration and physicochemical properties for providing a desired therapeutic effect, but it is not necessary that it possess the optimal molecular framework and properties to ensure delivery at the targeted site of action. In such cases only a small fraction of the
Nuclear receptors are very important for the functioning of various molecules in our body. They are basically proteins found in the interior aspects of the cell. They sense the presence of small lipophilic molecules like steroids and various other hormones and regulate the expression of the genes concerned to these molecules.
She also noticed swelling around her ankles, but attributed it to the demands of being on her feet all day. After migrating to Britain her shortness of breath began to intensify. The condition worsened until she was
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