Health Sciences & Medicine
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One of the most widespread human virus, which expands worldwide during human lives is a virus of the herpes family, Epstein-Barr virus (EBV), also called Human herpesvirus 4. According to National Center of Infection disease, in the United States 95% of adults between 35 and 40 years of age have been infected and the most common age of infection is 21 years.


It has a complex managing of viral lifecycle not usual as many viruses, and Henle and Hausen has succeed leading, maintaining and manipulating in continual latency, discovering EBV through immortalized B cells after infection in which it persist as episome -circularized genome. The path of spreading through distinct gene expression categorized in two groups , lytic cycle try expressing viral protein and spreading through virions and latent cycle in which different set of viral protein are produced such as antigen, membrane protein encoded RNAs spreading try at least twenty micro RNAs in infected cell. Clinical symptoms of primary infection often manifested as mononucleosis and appear through fever, sore throat and swollen gland and rarely it could develop in hepatosplenomegaly, heart problem or attack on the central nervous system and lymphadenopathy. Because the infection is almost never fatal, it usually resolves during 1 or 2 months, persisting in rest of the person's life EBV remains dormant in few cells in the throat and blood. Usually the virus periodically reactivates without symptoms manly in seropositive individuals and it could spread through macrophages via placenta infecting the fetus, commonly found in saliva. ...
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