Based on a study carried out, combined with references from previously carried out researches on cardiovascular disease. This article tries to explain the role of fibrate plus statin on PPTG (postprandial triglycerides) levels in patients with DM (diabetes mellitus). …
This article tries to explain the role of fibrate plus statin on PPTG (postprandial triglycerides) levels in patients with DM (diabetes mellitus). To begin with the article gives a brief preview of the various studies that have been carried out earlier on, it give the various findings that were deducted from this studies. These have been clearly stated to with only the important points regarding the study to be carried out stated. Basically, a larger part of this study is to approve of the various results, in studies that were carried out earlier and also to clarify the truth in the various theories formulated earlier, specifically in relation to the roles of fibrate plus statin on PPTG, because this is an area that has not been looked into carefully especially with the clinical trials. Further we then discus the in detail the methods that were used in carrying out the study which was approved by Columbia university medical centre institutional board. A randomized exercise was used in selecting the subjects of a subset enrolled in ACCORD lipid, this were 150 out of a potential participants, but only 139 were used in the study because some participants did not, based on the entry LDL-C (Low density lipoprotein- cholesterol), receive any simvastatin: those individuals amounting to 11 were excluded from the final analysis. In this study, the hypothesis was that combination therapy with fenofibrate and simvastatin (FENO-S) would result in lower (postprandial lipemia) PPL compared to therapy with placebo and simvastatin (PL-S). we have further illustrated and explained how the subjects were treated and the various variables that were used such as fenofibrate and simvastatin and placebo simvastatin, methods and quantities used to the subjects have been explained in detail and results carefully presented. The results comprise of the laboratory results which have been stated out clearly, the statistical explanations which have also been outlined with errors having been minimized as much as possible, and to top it up a variety of tables and graphs have been used to explaining the findings of the study. The results found in the study have not completely exhausted the explanation behind the role of fibrate plus statin on PPTG (postprandial triglycerides) levels in patients with DM (diabetes mellitus), but have given a strong ground on which other studies can be based on. This article also provides an extensive collection of articles and books that can aid in other studies related to this. Summary of the Results Putting in mind, many other studies have been carried out in this field with different results and conclusions drawn. The purpose of this study is to clarify most of the conflicting conclusions reached at regarding atherosclerotic cardiovascular disease and diabetes. Our hypothesis for this study was that fenofibrate plus simvastatin would result in a significantly lower PP lipoprotein levels compared to placebo plus simvastatin. We tried to be specific and precise as much as possible in presenting our results. The laboratory results were carefully analyzed and various testing and measurement methods used such as standard enzymatic techniques on a Roche Hitachi 912 chemistry analyzer, other methods were as per the requirements stated in various articles such as Low density lipoprotein (LDL) C levels were calculated by the Friedewald method which has been approved in earlier study by Friedewald, Levy and Drederickson (1972). Also ApoB48 levels, ApoCIII levels and HbA1c were measured in the laboratory. The statistics were used to come up with various tables and graphs which have been included in this article. While drawing the graphs for the postprandial incremental area under the curve (IAUC) ...
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