Got a tricky question? Receive an answer from students like you! Try us!

Rheumatoid Arthritis Exercises - Essay Example

Only on StudentShare
Pages 5 (1255 words)


RA is serious arthritis of inflammatory nature of unknown cause. In most patients this disease involves bilaterally symmetric chronic low-grade inflammation eventually progressing to involve multiple joints with periodic inflammatory flares (Kraus and Wiggin, 2009).

Extract of sample
Rheumatoid Arthritis Exercises

The onset of the disease is most frequent in fourth and fifth decades of life (Luqmani et al., 2006).
The aetiology of the disease is not specifically known and has been suggested to be multifactorial. The class II major histocompatibility complex allele HLA-DR4 and related alleles are known to be major genetic risk factors for RA. It has been suggested that RA might be a manifestation of the response to an infectious agent in a genetically susceptible host. Activation of autoimmune mechanisms is the key aetiologic event in sustaining the chronic inflammatory process so characteristic of RA (Scott et al., 2000).
The main event in pathophysiology is inflammatory synovitis. Subsequently through a cascade of multiple immune events through mediation of a host of immune cells, the synovial fibroblasts are activated. Added to cartilage degradation, osteoclasts are activated that leads to erosion of bone. The chemokines and cytokines lead to synovitis, cartilage and bone damage, and systemic manifestations of RA (Luqmani et al., 2009). Altman (2008) notes that these immunologic abnormalities arise from various immune complexes, which originate from the inflamed synovial cells that serve as a target for such immune injuries. The plasma cells that are recruited produce antibodies known as rheumatoid factors. These actively contribute to these complexes which ultimately lead to joint destruction. ...
Download paper
Not exactly what you need?

Related Essays

Preventing of Gouty Arthritis
This directed the need to study prophylaxis with colchicines for different durations. This article reviews the trial conducted to study different duration of colchicines for preventing recurrence of Gouty arthritis and critique the methodologies used and recommends areas of future research.…
6 pages (1506 words)
Exercises 4
interest if we were to hold this cash with bank or any other investment opportunity.…
2 pages (502 words)
finance exercises
The CVP Equation is Sales = Variable Cost + Fixed Cost + Profit. This is a simplified equation and is structured into both fixed and variable expenditure. Its objective is to identify the contribution needed to cover fixed cost…
3 pages (753 words)
Critical review of Rheumatoid arthritis
However, RA involves an attack on the body by its own immune cells (auto-immune disease). Different cases may have different causes. Infectious, genetic, and hormonal factors may play a role. The disease can occur at any age, but it begins most often between the ages of 25 and 55. The disease is more common in older people. Women are affected 2.5 times more often than men. Approximately 1-2% of…
6 pages (1506 words)