StudentShare solutions
Triangle menu

Therapeutic Use Of Stem Cell For Treatment Of Parkinsons Disease - Essay Example

Extract of sample
Therapeutic Use Of Stem Cell For Treatment Of Parkinsons Disease

Parkinson's disease is a very common neurodegenerative disorder that tends to present late in life. It is a disease with a lifetime incidence of 2.5% and a prevalence of at least 2% in individuals over 65 - 70 years of age. Millions of humans are victims of this neurodegenerative disease [1]. It is caused by a progressive degeneration and loss of nigrostriatal dopamine-containing neurons. Sometimes degeneration also occurs in systems of non-dopaminergic neurons [2]. The common symptoms of Parkinson's disease are tremor, rigidity, and hypokinesia (abnormally decreased mobility). Together with these problems various degrees of cognitive, autonomic, and psychiatric abnormalities may also be present [1].
The dopaminergic neurons have their cell bodies located in the substantia nigra pars compacta (SNpc). These special neurons send axons to the caudate and putamen which is collectively known as the corpus striatum. The gradual degeneration of these cells initiates a chain of disorders. Degeneration results in the ongoing decrease over time of striatal dopamine levels which is very essential for normal functioning. This in turn produces a decline in striatal output to the thalamus. These alterations result in a decrease in cortical motor output. This decrease can account for some of the observed motor symptoms, particularly bradykinesia and rigidity, but other features such as a resting tremor probably have a largely non-dopaminergic component [1].

Till date there are several treatments available for Parkinson's disease however medical science has failed to find a complete cure for this disease. Treatments involving drugs target the dopaminergic nigro-striatal pathway. Unfortunately, it is found that over time the efficacy of these medications is limited by the development of profound motor fluctuations and dyskinesias[1]. The common drug is the oral administration of l-dopa and dopamine receptor agonists, and deep-brain stimulation in the subthalamic nucleus. These treatments are effective for some symptoms, but are associated with side effects and do not stop the progression of the disease [2].

Therapies that completely cure patients of Parkinson's disease is yet to be found, but stem cell therapies offer exciting possibilities [1, 3]. Stem cells have the incredible potential to develop into many different cell types in the body. Serving as a sort of repair system for the body, they can theoretically divide without limit to replenish other cells as long as the person is alive. To be clinically competitive, a stem-cell-based therapy must lead to long-lasting, significant improvement in mobility, ameliorate currently intractable symptoms, or counteract disease progression. Besides, to make stem-cell therapy work, dopaminergic neurons with the characteristics of substantia nigra neurons must be produced in large numbers [1].

Today, stem cell-based therapies might be a turning point in medical science that might represent in the near future a plausible alternative strategy in these disorders. However, it is important to consider the challenges before envisaging any human applications of stem cell-based therapies in neurological diseases. For instance, the questions such as which is the ideal stem cell source for transplantation, what are the most appropriate route of stem cell ...Show more

Summary

Research on stem cells has provided enough evidence of making them uniquely situated to treat a broad spectrum of human diseases. The ability of stem cells to participate in brain repair particularly in the case of Parkinson's disease has been increasingly demonstrated in recent studies…
Author : annabell13
Therapeutic Use Of Stem Cell For Treatment Of Parkinsons Disease essay example
Read Text Preview
Save Your Time for More Important Things
Let us write or edit the essay on your topic
"Therapeutic Use Of Stem Cell For Treatment Of Parkinsons Disease"
with a personal 20% discount.
Grab the best paper

Related Essays

Stem Cell
There is almost no area of medicine that will go untouched by this revolutionary research. As a person who comes from a family that has been impacted by hereditary, late-onset Parkinson's, the possibility that my grandchildren may be freed from the fear of this disease gives our family great optimism.
2 pages (500 words) Essay
Parkinsons Disease
Parkinsons disease (PD) is a common progressive neurodegenerative disorder that is characterized by the loss of striatal dopamine (DA) as a result of degeneration of dopaminergic (DAergic) neurons in sunstantia nigra, thus, produces progressive disability.
8 pages (2000 words) Essay
About republicans (you decide)
In general, political scenarios change instantaneously, i.e. democrats and republicans, whoever comes to power starts with new ideologies to develop. But their ideology may counter to the thoughts
12 pages (3000 words) Essay
Parkinsons disease
Ellis, 210) which causes a huge burden on the sufferer himself, his carers, family and the over all medical systems (Rubenstein, 305) Its occurrence is seen in less than 50 years of age one out of seven patients, and the occurrence increases with the increase in age. At
4 pages (1000 words) Essay
Parkinsons Disease
Despite many studies conducted about the disease, the cause of it is unknown. It is known that the mutation of genes in the family will likely to pass it on to the next generation. Factors like toxins, smoking, and vitamin E deficiency is shown to play a role in its prevalence to as the brain and the nervous systems are sensitive to their presence.
7 pages (1750 words) Essay
Stem Cell
arch for the wellbeing of human since it believes that stem cell research can find answers to some of the genetic diseases and other serious diseases like cancer, heart problems etc. For example, around 30,800 annual leukemia cases are reported in USA including 10,800
6 pages (1500 words) Essay
Correcting Sickle Cell Disease using Stem Cells
The disease manifests after 4 months of age, and its symptoms include painful episodes that last from hours to days, breathlessness, delayed growth, fatigue, fever, rapid heart rate,
1 pages (250 words) Essay
Diabetes and Stem Cell Treatment
However, in recent times, research has led to the discovery of new means to manage the disease, although, only for minimal patients. The aim of this paper is to explain the
4 pages (1000 words) Essay
Review the current and potential future treatments for Parkinsons Disease
It shall illustrate Parkinson Disease, its symptoms, pathology, genetics, aetiology, and explores current and future treatments of the disease. Parkinson ’s disease is a chronic neurodegenerative disorder of the central
14 pages (3500 words) Essay
Stem Cell
According to the report there are a lot of ethical issues surrounding the use of stem cells in research and treatment. There are two types of stem cells as outlined by the American Medical Association and these include adult stem cells as well as the embryonic stem cells. These stem cells can be transformed into any type of cell.
6 pages (1500 words) Essay
Get a custom paper written
by a pro under your requirements!
Win a special DISCOUNT!
Put in your e-mail and click the button with your lucky finger
Your email
YOUR PRIZE:
Apply my DISCOUNT
Comments (0)
Rate this paper:
Thank you! Your comment has been sent and will be posted after moderation