The mainstay of breast cancer care is local therapy consisting of surgery along with systemic adjuvant therapy, which includes chemotherapy, hormonal or a combination therapy. Besides major advances in managing both early and locally advanced breast cancer, patients still have to deal with severe side effects of fatigue during adjuvant therapy resulting in substantial impact on patients' quality of life (Markes, Brockow and Resch, 2006).
Most cancer patients would say that fatigue is a major obstacle to functioning normally (Portenoy & Itri, 1999). Fatigue is a distinctive, dominant symptom in patients with cancer, that impacts life functional ability and occupational status. The fatigue diminishes the patient's ability to do both physical and mental tasks, as it has physical, affective, and cognitive components of the symptom (Dalakas, Mock and Hawkins, 1998). This kind of fatigue is referred as cancer-related fatigue or CRF.
Cancer-related fatigue (CRF) as defined by the National Comprehensive Cancer Network "is an unusual persistent, subjective sense of tiredness related to cancer treatment that interferes with usual functioning" (NCCN, 2005).
Since fatigue is not directly observable in most of its forms, its importance and treatment are often overlooked (Newell, Sanson-Fisher, Gir ...Show more