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Obesity-A public health crisis :A complex problem with simple solutions As a review - Essay Example

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Obesity-A public health crisis :A complex problem with simple solutions As a review

The genetic approach in human and animal models relates obesity to body weight regulation. Monogenic type of obesity in man is characterized and emerges from mutation of genes in the central pathways of food consumption regulation. But these types of obesity cases are rare and obesity is normally understood as a complex polygenic health issue that increases interaction between the environment and multiple genes. Several studies including research on children have strived to find the susceptibility genes. Currently, the outcomes of the research are inconclusive because it is highly variable between researches and also due to the risk involved with a specific gene allele obesity is low. Therefore, it is premature to classify obese patients based on genotype for predictive testing. 2
Nutrient gene interaction relates to the differential functional and the subsequent phenotypic effects of various doses of specific ingredients or energy intake together with various gene variants. The gene interaction explains inter individual variations within a species. 3
The effect of gene-gene interaction is found in extreme cases and immune dysfunction in obesity. The interactions between the variants of β-adrenergic receptor genes lead to longitudinal weight differences in Caucasian and African American subjects. The gene-gene three way interactions affect the abdominal fat. 4
Like many other diseases, obesity is a genetic health problem. A research using a dense genome scan of DNA specimen from Framingham Heart Study participants was used to find a common genetic variant close to the INSIG2 gene related to obesity. The replication of the findings in four different specimens using participants of African Americans, Western Europe ancestry and children revealed that obesity predisposing genotype was found in ten percent of the individuals. The research reveals that common genetic polymorphism is a significant determinant of obesity.5
An assessment of β2- ...Show more


Children with obesity grow up to become obese adults. There has been an exorbitant increase in the rate of pediatric obesity along with the parallel rapid increase in the rate of adult obesity. As obese…
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