Chemotherapy: High Risk Complications Wesling Ducos Advanced Med-Surg 6-26-12 Chemotherapy: High Risk Complications Introduction In chemotherapy treatment, the drugs used to cure cancer can have a number of high risk complications including adverse reactions and toxicities…
Chemotherapy-related Nephrotoxicity Studies indicate that chemotherapeutic drugs may damage glomerulus, renal tubules, or microvasculature and thereby lead to renal problems. Adverse reactions can be mild or fatal. Some commonly used nephrotoxic antineoplastic agents like Cisplatin may develop proximal and distal tubule damages. The injury level may vary in accordance with the dosage. High dose cisplatin therapy would result in acute tubular necrosis, which is a condition limiting tubules’ sodium, magnesium, and water reabsorption capabilities. This condition in turn may lead to chronic electrolyte abnormalities too. “Even when aggressive pre and posthydration with mannitol induced diuresis are part of the cisplatin regimen, the patient may develop nephrotoxicity” (Held-Warmkessel, 2011) In order to reduce those risks, it is necessary to closely monitor renal activities following the drug administration. Similarly, methotrexate causes damage to renal tubules and collecting ducts and ultimately results in acute tubular necrosis. While giving high dose therapy, drug precipitates out of the solution and is accumulated in tubules ducts; this condition may worsen the injury. Acute kidney injury is more likely to occur at any time during this treatment. To minimize the renal risk chances associated with high dose therapy, patients are given sodium bicarbonate containing I.V. fluids (Sodium Bicarbonate, n.d). Through this hydration technique, it can also alkalinize urine. The urine pH testing begins prior to hydration and lasts until the methotrexate is eliminated from the body. Over the treatment period, it is essential to closely monitor the methotrexate drug levels periodically. Major signs and symptoms of chemotherapy related nephrotoxicity may include excess or deficit fluid volume, electrolyte abnormalities such as hyperkalemia and hypocalcemia. Sometimes, nausea and vomiting are observed as major symptoms of this condition. According to Held-Warmkessel, nursing interventions mainly focus on collecting patient history, physical assessment performance, identification of nephrotoxicity risk factors, and lab results review. In addition, it would be better to pay specific attention to potential nephrotoxic medications the patient takes regularly, like nonsteroidal anti-inflammatory drugs. Checking the patient for signs and symptoms of excess or deficit fluid volume and drug toxicity is also important. Febrile Neutropenia Febrile neutropenia is the most potential high risk complication of chemotherapy because this condition may cause even stable patients to develop hemodynamic instability and critical illness. The victim may die unless prompt monitoring and interventions are conducted. As Bolyard., Cottle., Edwards., Kinsey., Schwinzer & Zeidler (n.d) point out, neutropenia is diagnosed when the patient’s absolute neutrophil count falls below 500 cells/mm3. In patients having a hematologic malignancy, neutrophils are inactive and unable to effectively fight infection even though the absolute neutrophil count lies within the normal range. Likewise, white blood cells including neutrophils play a key role in maintaining body’s cellular immunity. According to Held-Warmkessel (2011), neutrophils are the first respondents in an infection site and they prevent progressive infection. The chemotherapy procedure kills bone ...
Cite this document
(“Chemotherapy: High-Risk Complications Research Paper”, n.d.)
Retrieved from https://studentshare.net/nursing/68540-high-risk-chemotherapy-complications-to-watch-for
(Chemotherapy: High-Risk Complications Research Paper)
“Chemotherapy: High-Risk Complications Research Paper”, n.d. https://studentshare.net/nursing/68540-high-risk-chemotherapy-complications-to-watch-for.
The heightened concern regarding the issue on falls in the inpatient setting enabled research on risk factors on falls and fall management strategies to be extensive and many fall prevention programs had been proposed at the course of time. This study will identify the patients at high risk for falls in a community hospital setting and present a fall prevention program for this vulnerable group.
As neutrophils have a short lifespan and a very fast turnover, they can be particularly sensitive to many types of chemotherapy (Wood & Pizzo, 1993), meaning that patients undergoing cancer treatment often present with neutropenia and the related symptoms (Kuderer et al, 2007).
It may be related – like many other difficult decisions in the life of a woman – to feelings of sadness, regret, guilt or loss. But each alternative is also linked to psychological problems, especially the decision to give the child in adoption. An unwanted pregnancy is associated with an increased risk of psychological problems.
Such measures are particularly important for those who have risk factors that cause blood pressure.Managing blood pressure is one of the most important things that anyone can do to decrease the risk of stroke and heart diseases as most patients of high blood pressure face severe heart problems and heart diseases (Sheps 33).
This research paper aims to discuss the likelihood of the Facebook users to be at a risk of depression. The subject of Facebook users and their likelihood of being at risk of depression is considerably a newer area of research because different patterns of behavior of individuals associated with Facebook have been observed.
This paper seeks to discuss the social and economic issues associated with a steadily ageing population particularly ageing populations and pensions, health care, long-term care and disability, as well as the economy. The objective is to shed more light on how manageable that transition to old age might be, or will portend to the society. It is self evident that an ever increasing population of the elderly will predictably over whelm the resources available, at a national and global level.
The author states that the symptoms and complications of neutropenia are immune system related, and include high fever and frequent infections and is diagnosed with a blood cell count. The suggested intervention is giving information and education to both patients and clinical staff about the dangers, risks and avoidance of neutropenia.
The patient is referred due to her pregnancy being high risk. First, she has a bad obstetric history, having lost seven of the previous pregnancies. She has conceived nine times and has only one surviving child. Further, it is also identifiable that the current pregnancy is
7 Pages(1750 words)Research Paper
GOT A TRICKY QUESTION? RECEIVE AN ANSWER FROM STUDENTS LIKE YOU!
Let us find you another Research Paper on topic Chemotherapy: High-Risk Complications for FREE!