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Describe and then critically analyze a recently published pathophysiology research article
Pages 4 (1004 words)
Pathophysiology Research Article Assignment Your Name Your institution Pathophysiology Research Article: Critical Analysis Andrade, B. B., Reis-Filho, A., Souza-Neto, S. M., Clarencio, J., Camargo, L. M., Barral, A., & Barral-Netto, M. (2010). Severe Plasmodium vivax malaria exhibits marked inflammatory imbalance.
There are two main species of malaria worldwide which cause the majority of cases. Plasmodium vivax has been considered for a long time as a benign and self-limited species, while Plasmodium falciparum is the species known to cause serious disease and death. Plasmodium vivax accounts for the majority of malaria cases in the Brazilian Amazon region. Recently there have been reports that malaria caused by P. vivax may be as severe as P. falciparum. The complications of P. vivax infection represent a significant global health menace, which needs focused efforts to work for its resolution. In severe falciparum malaria, as in many other systemic infections, most of the pathology that is described seems to be a consequence of an intense inflammatory response, produced by a pathological over-activation of the immune system and excessive cytokine release. However, there have been no previous studies on the inflammatory and immunological status of both mild and severe vivax malaria disease. In order to understand the immunopathological events in vivax malaria, and to differentiate its pathophysiology from P. falciparum, it is important to explore the pattern of cytokines released in patients suffering from P. vivax malaria. ...
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