However, due to cholinergic stimulation and epithelial lining irritation, the stomach and duodenum epithelial cells secrete mucus which is basically impermeable pepsin and acid. A mucosal injury which leads to the formation of peptic ulcer disease occurs as a result of an imbalance between the defensive mechanisms and aggressive factors. Aggressive factors include bile salts, pepsin, acid, alcohol, NSAIDS and H pylori infection. The defensive mechanisms include mucus, cellular restitution, epithelial renewal and mucosal blood flow (Anand & Katz, 2011). The aggressive factors affect the mucosal defense hence allowing the hydrogen ion diffusion which leads to epithelial cell damage or injury.
2. Hypothesis 3: Gastroenteritis- Gastroenteritis is the inflammation or infection of the stomach or intestines. H pylori bacteria is the primary cause of the disease. Normally it is acquired during a person’s childhood. Once in the stomach, Helicobacter pylori pass via the mucous layer and subsequently establishes itself at the stomach’s luminal surface hence causing an inflammatory response from the tissue underlying it (Bresee et al, 2012).
Upon a close analysis of the patient’s symptoms, it can be concluded that she was suffering from Cholecystitis. The patient depicted all Cholecystitis symptoms (overweight/ fat, nausea, over 40 years, female, Pain in the abdomen or upper tummy, and vomiting). Lack of black or dark stool, blood in her stool, and weight loss ruled out the possibility of Peptic ulcer perforation while her act of emptying her bowels normally ruled out the possibility of Gastroenteritis.