Microtubules - Essay Example

Only on StudentShare

Extract of sample
Microtubules

Microtubules

Again, these mechanisms need further exploration but the existing understanding is that reorganization of F-actin causes destabilization of transinteraction between TJ and AJ proteins of the adjacent epithelial cells and in turn initiate AJC internalization.

Microtubules, which are also an important element of intracellular cytoskeleton have also been found to be closely related to the cell movement as a whole or any intracellular structure formation like, vesiscles and their movement. Data support the abundance of microtubules in differentiated renal and intestinal cells and depolymerization of microtubules leading to disruption of the integrity of TJs and Ajs in some tissues like lungs. This evidence led the author to explore the role of microtubules depolymerization in the disruptions of apical junction complex.

Existing evidence strongly support the role of microtubules depolymerization in the disruption of intercellular connections like tight junctions and adherens junction in various tissues and helps in the pathogenesis of various disease processes. In this regard it has been shown that the endothelial intercellular junctions are also disassembled as well as others like in the brain. Building a rationale on the basis of these data, author formulated a hypothesis: ‘microtubules are involved in the disruption of apical junctions in simple epithelial cells’. ...
Download paper

Summary

Author has reviewed extensively the available data for developing a rationale to carry out this research work. This literature review has not only been quantitatively but also qualitatively well chosen to support the current research work. …
Author : qgoodwin

Related Essays

Research Paper Critique and Summaries
The research study proceeds from the assumption that "countries with a higher score on the collectivism index are more likely to favour the personal selling promotion tool than will countries with a lower score" (248). While this assumption is solidly grounded in the study's literature review, the authors subject it to further empirical examination. Utilizing an experimental design, Fam and Merrilees (1998) distributed a survey questionnaire amongst retail managers in both Australia and Hong Kong. Receiving a 40.2% in Australia and a 16% response in Hong Kong, Fam and Merrillees' (1998)…
4 pages (1004 words) Essay
Research Paper Critique (HRM)
Like most of the research agendas of IHRM researchers the writers have tried to tried to present human resource management in the context of organizations and their environment as well as with in the context of changing economic and business conditions.…
16 pages (4016 words) Book Report/Review
How should WTO member states respond to the issue of access to medicines as provided for in the DOHA AGREEMENT for trips
International trade in the olden days was often marked with conflicts, disputes or even violence that threatened sprouting of wars between contracting nations. Thus, the lex mercatoria or law merchant came into being to govern international trade, all international merchants and especially monopolistic chartered companies such as the East India Company, South Sea Company and the Hudson Bay Company which needed to be reined over to protect small-scale merchants . Suddenly, international commercial arbitration governed by lex mercatoria was utilised to settle international trade disputes. Here,…
16 pages (4016 words) Essay
Cellular processing of Alzheimer’s amyloid precursor protein
Cellular processing of Alzheimer’s amyloid precursor protein …
3 pages (753 words) Essay
Cell Biology
They found out that when antibodies of GRASPs were introduced, daughter cells resulting from mitosis had improper stacking of cisternae membranes.…
3 pages (753 words) Essay
Microtubules
This interaction, revealed by the structure, is branded the EB1-like motif and there is possibility that the binding interaction of CLIP family depends on this. Intuitively, considering that CLIP experiences binding at the acidic tail of tubulin, it is also possible that the acidic tail of EB1 also provides the same condition allowing for binding. 12…
11 pages (2761 words) Lab Report
Microtubules
Microtubules are polymers that have elongated tube-like monomer chains. These chains are helical like. α-βtubulin subunits make up the helical tube that has 13 protofilaments that are aligned in a parallel way. The subunits enable the tube-like monomers to link with each other using vertical and lateral bonds. The α-tubulin domain bind to the β-tubulin domain forming these bonds. Hence, the mechanical strength of the microtubules is enhanced. The Microtubule Organizing Centre mediates the nucleation of the microtubules. It comprises a ring complex of γ-TURC and γ-tubulin (Atkinson, 2014,…
7 pages (1757 words) Other types
Got a tricky question? Receive an answer from students like you! Try us!