The Last Supper by Leonardo da Vinci is famously recognized paintings in history. It shows the story of the last supper of Jesus with his disciples. The painting is remarkable as it depicts the disciples as real human beings. In the painting, Leonardo tried to use new materials due to the thought that it would result in an extensively varied palette. In his work, Leonardo sought to illuminate the painting beyond what could traditional fresco give. He thus used unreal fresco as he was working on a dry wall. Borrowing, from the panel painting, he applied a white lead to improving on the brightness of the tempera and oil he had used on top. In conclusion, the two paintings from the two periods have certain differences that portray cultural change. The Annunciation painting has medieval painting styles. It included panel painting, illuminated manuscripts, sculpture, and fresco. Even though Leonardo used the fresco, it was not real forcing him to apply a white lead to improving the brightness of the painting. In the period, which started in the late middle ages, European continent started evolving into big states controlled by monarchies. The Italian urban centers expanded due to growth of population and expansion of trade. Land paved way for money as the means of exchange thus freeing the serfs. The changes brought cultural, social, and economic changes. Literacy increased leading to the expansion of vernacular literatures that led people to adopt secular themes in their arts. The growth of wealth.